Biochemistry of Jaundice - Problems and Mechanisms related to Jaundice
Biochemistry of Jaundice - Problem related to Jaundice, Mechanism of Jaundice 1. Explain why with hereditary defects in heme synthesis enzymes, the skin of patients has an increased sensitivity to solar radiation, and urine acquires a red color. The accumulation of what intermediate products of heme synthesis causes these symptoms? As we know, the synthesis of heme takes place in the cytosol and mitochondria of our cells. Acquisition of heme also occurs through intestinal absorption and intracellular transport. Hem is a component of various biological structures, mainly hemoglobin, others include myoglobin, cytochromase, catalease, heme peroxidase, and endothelial nitric oxide synthase. The most common type is heme B, which is found in hemoglobin which leads to derivations of other heme groups. 5'-Aminolevulinic acid synthase (ALA-S) is an enzyme regulated for heme synthesis in our body's liver and erythroid cells. ALA Synthase has two forms, the first one is ALAS1, and the sec...